| Product Name | ply Antibody |
| Cat Number | HR1AP0004 |
| Source | Rabbit |
| Applications | ELISA |
| Species Reactivity | Streptococcus pneumoniae serotype 4 |
| Storage | Store at -20?C or -80?C. Avoid repeated freeze. |
| Purification | >95%, Protein G purified |
| Clonality | Polyclonal |
| Isotope | IgG |
| Gene ID | 66806991 |
| Alternative Name | ply antibody; SP_1923 antibody; Pneumolysin antibody; Ply antibody; Thiol-activated cytolysin antibody |
| Background | A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. |
| Type | polyclonal |