| Product Name | Crk II Polyclonal Antibody |
| Cat Number | HR1AP3163 |
| Source | Rabbit |
| Applications | WB,IHC-p,IF,ELISA |
| Species Reactivity | Human,Mouse,Rat,Monkey |
| Storage | -20°C/1 year |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Observed Band | 40 |
| Gene ID | CRK |
| Alternative Name | CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38 |
| Background | CRK proto-oncogene, adaptor protein(CRK) Homo sapiens This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008], |
| Type | polyclonal |