| Product Name | Perforin 1 Polyclonal Antibody |
| Cat Number | HR1AP9621 |
| Source | Rabbit |
| Applications | WB,IHC,ELISA |
| Species Reactivity | Human |
| Storage | -20°C/1 year |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Observed Band | 61 |
| Gene ID | PRF1 |
| Alternative Name | Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP) |
| Background | perforin 1(PRF1) Homo sapiens The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008], |
| Type | polyclonal |