| Product Name | Cleaved-MASP-1 HC (R448) Polyclonal Antibody |
| Cat Number | HR1AP2178 |
| Source | Rabbit |
| Applications | WB,ELISA |
| Species Reactivity | Human |
| Storage | -20°C/1 year |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Observed Band | 47 |
| Gene ID | MASP1 |
| Alternative Name | MASP1; CRARF; CRARF1; PRSS5; Mannan-binding lectin serine protease 1; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease |
| Background | mannan binding lectin serine peptidase 1(MASP1) Homo sapiens This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[p |
| Type | polyclonal |